SLK (gene)

STE20-like kinase

PDB rendering based on 2j51.

Available structures
PDB	2J51, 2JFL, 2JFM, 2UV2

Identifiers

Symbols

SLK; KIAA0204; LOSK; MGC133067; STK2; bA16H23.1; se20-9

External IDs

MGI: 103241 HomoloGene: 22515 GeneCards: SLK Gene

EC number

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • DNA binding • nuclease activity • protein serine/threonine kinase activity • ATP binding
Cellular component	• cytoplasm • plasma membrane
Biological process	• nucleotide-excision repair • apoptosis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
105.73 – 105.79 Mb

Chr 19:
47.65 – 47.72 Mb

PubMed search

[1]

[2]

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.^[1]^[2]

Interactions

SLK (gene) has been shown to interact with PDZK1.^[3]

References

^ Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science 233 (4769): 1175–80. doi:10.1126/science.3526554. PMID 3526554.
^ "Entrez Gene: SLK STE20-like kinase (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9748.
^ Gisler, Serge M; Pribanic Sandra, Bacic Desa, Forrer Patrik, Gantenbein Andrea, Sabourin Luc A, Tsuji Akira, Zhao Zhuo-Shen, Manser Edward, Biber Jürg, Murer Heini (Nov. 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. (United States) 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. ISSN 0085-2538. PMID 14531806.

Yan Y, Nguyen H, Dalmasso G, et al. (2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform.". Biochim. Biophys. Acta 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMC 1865517. PMID 17321610. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1865517.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chaar Z, O'reilly P, Gelman I, Sabourin LA (2006). "v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II.". J. Biol. Chem. 281 (38): 28193–9. doi:10.1074/jbc.M605665200. PMID 16837460.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.
Dan I, Watanabe NM, Kusumi A (2001). "The Ste20 group kinases as regulators of MAP kinase cascades.". Trends Cell Biol. 11 (5): 220–30. doi:10.1016/S0962-8924(01)01980-8. PMID 11316611.
Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens.". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14639.
Yamada E, Tsujikawa K, Itoh S, et al. (2000). "Molecular cloning and characterization of a novel human STE20-like kinase, hSLK.". Biochim. Biophys. Acta 1495 (3): 250–62. doi:10.1016/S0167-4889(99)00164-0. PMID 10699464.
Sabourin LA, Tamai K, Seale P, et al. (2000). "Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region.". Mol. Cell. Biol. 20 (2): 684–96. doi:10.1128/MCB.20.2.684-696.2000. PMC 85169. PMID 10611247. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85169.
Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.

PDB gallery

2j51: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 5-AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

2jfl: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2, 4-TRIAZOLE-1-CARBOTHIOAMIDE

2jfm: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)

2uv2: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 4-(4-(5-CYCLOPROPYL-1H-PYRAZOL-3-YLAMINO)-QUINAZOLIN-2-YLAMINO)-PHENYL)-ACETONITRILE

SLK (gene)

Interactions

References

Further reading